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- One shot to stop HIV: MITs bold vaccine breakthrough
Massachusetts Institute of Technology "One shot to stop HIV: MIT's bold vaccine breakthrough " ScienceDaily ScienceDaily, 20 June 2025 <www sciencedaily com releases 2025 06
- Supercharged vaccine could offer strong protection with just one dose
That nanoparticle, known as SMNP, is now being used as an adjuvant for an HIV vaccine that is currently in clinical trials Irvine and Love then tried combining alum and SMNP and showed that vaccines containing both of those adjuvants could generate even more powerful immune responses against either HIV or SARS-CoV-2
- Step by Step Scientists Move Closer to an HIV Vaccine Breakthrough
In a breakthrough study published in Science, scientists from IAVI and Scripps Research have reported results from two separate but complementary Phase 1 clinical trials that demonstrate an innovative vaccination strategy might finally be able to teach the immune system how to generate bnAbs
- One Shot To Stop HIV: MITs Bold Vaccine Breakthrough
ScienceDaily reports: Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies
- Groundbreaking HIV supercharged vaccine could protect well with just . . .
More powerful vaccine While alum has long been a staple in protein-based vaccines for hepatitis A and B, its partner SMNP — a compound containing saponin and MPLA — is a newer entrant derived from the Chilean soapbark tree Developed by Irvine, SMNP has already proven its mettle in early-stage HIV vaccine trials
- Two-part vaccine strategy generates a stronger, longer-lasting immune . . .
Vaccines work by teaching the body to recognize dangerous viruses and bacteria, but HIV has proven to be a particularly challenging target because it mutates rapidly and hides from immune defenses To explore how to tackle this issue, the research team used an experimental HIV protein called MD39—a type of antigen, or molecule that triggers an immune reaction
- Twice-a-year shot to prevent HIV could stop transmission — if people . . .
While a vaccine to prevent HIV still is needed, some experts say the shot made by Gilead Sciences — a drug called lenacapavir — could be the next best thing It nearly eliminated new infections in two groundbreaking studies of people at high risk, better than daily preventive pills they can forget to take
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