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Canada-270253-BUILDING INSPECTIONS företaget Kataloger
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Företag Nyheter:
- A systematic review and meta-analysis of endocrine-related . . .
Our meta-analysis shows a high incidence of endocrine adverse events related to interferon therapy, which is further enhanced by combined therapy Hypothyroidism is the most common thyroid disorder, followed by hyperthyroidism
- Side Effects of Interferon Alpha in Viral Hepatitis
Rare Adverse Events Ocular: Retinopathy has been reported in Japanese patients (27) Lung: interstitial fibrosis of the lung and hearing impairment have been found (7) The cases of pneumonitis may also be due to the use of Sho-Saiko and interferon (28) Conclusion
- The interferon gene signature as a clinically relevant . . .
The interferon gene signature (IGS) is derived from the expression of interferon-regulated genes and is classically increased in response to type I interferon exposure A raised whole blood IGS has increasingly been reported in rheumatic diseases as sequencing technology has advanced
- Type I interferon gene signature test-low and -high patients . . .
IFNGS test-low patients had significant enrichment of eosinophil (Q < 0 001), IFN-γ-specific (Q = 0 005), and T-cell or B-cell (Q < 0 001) signatures Similar enrichment profiles were demonstrated in patients with primary Sjögren's syndrome, systemic sclerosis, and dermatomyositis
- Too Much of a Good Thing: Detrimental Effects of Interferon
Adverse side effects can include fever, fatigue, myalgia, major depressive disorder, and autoimmunity It is therefore not unexpected that a prolonged and sustained action of IFNs in response to infection or due to an inherited dysregulation of IFN homeostasis can promote pathogenic effects [7, 8] 1 2 Sentinel Receptors
- Adverse effects of high-dose interferon-alpha-2a treatment . . .
Adverse effects that led to dose reduction or early discontinuation of IFN treatment occurred in 19% of patients and included impotence, depression, seizure, thyroid disorders, severe thrombocytopenia, and intestinal bleeding
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