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Canada-0-TATTOOS företaget Kataloger
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Företag Nyheter:
- Excitotoxicity: Could a New Class of Drug Stop a Bad TRP?
These prevented excitotoxicity (right) [Courtesy of Yan et al , 2020 Science AAAS ] Yan found that TwinF bound to a stretch of 18 amino acids on the cytosolic side of GluN2A and GluN2B, close to the membrane Bading dubbed this region I4 because it contains four regularly spaced isoleucines Other glutamate receptor subunits lack this motif
- Excitotoxicity, calcium and mitochondria: a triad in synaptic . . .
Verma M, Lizama BN, Chu CT Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration Transl Neurodegener 2022 Jan 25;11 (1):3 PubMed
- A neuroprotective role for microRNA miR-1000 mediated by . . . - ALZFORUM
Glutamate excitotoxicity has been put forward as one of the mechanisms at play in Alzheimer’s disease and other neurodegenerative conditions In this paper, Verma et al describe a very interesting microRNA-mediated mechanism for fine-tuning glutamatergic signaling that, when disturbed, can lead to neurodegeneration They demonstrate how dysregulation of the activity-dependent miR-1000 in
- NX210c - ALZFORUM
NX201 and NX201c both protected neurons from glutamate excitotoxicity by disrupting the apoptotic signaling cascade; NX210c was more effective (Deletage et al , 2021) NX210c increased synaptic transmission in brain slices, and improved memory in mice treated with the NMDAR agonist phencyclidine (Lemarchant et al , 2022)
- Acute and chronic excitotoxicity in ischemic stroke and late-onset . . .
Yu SP, Choi E, Jiang MQ, Wei L Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease Neural Regen Res 2025 Jul 1;20 (7):1981-1988
- Oncogene AEG-1 promotes glioma-induced neurodegeneration by . . . - ALZFORUM
Lee SG, Kim K, Kegelman TP, Dash R, Das SK, Choi JK, Emdad L, Howlett EL, Jeon HY, Su ZZ, Yoo BK, Sarkar D, Kim SH, Kang DC, Fisher PB Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity Cancer Res 2011 Oct 15;71 (20):6514-23 PubMed Recommends Please login to recommend the paper
- Inflammatory cytokines disrupt astrocyte exosomal HepaCAM-mediated . . .
Jin S, Tian Y, Hacker J, Chen X, Bertolio M, Reynolds C, Jarvis R, Hu J, Promes V, Halim D, Gao FB, Yang Y Inflammatory cytokines disrupt astrocyte exosomal HepaCAM-mediated protection against neuronal excitotoxicity in the SOD1G93A ALS model
- Biochemical abnormalities and excitotoxicity in Huntingtons disease . . .
Tabrizi SJ, Cleeter MW, Xuereb J, Taanman JW, Cooper JM, Schapira AH Biochemical abnormalities and excitotoxicity in Huntington's disease brain Ann Neurol 1999 Jan;45 (1):25-32 PubMed
- Dendritic function of tau mediates amyloid-beta toxicity in . . . - ALZFORUM
Fourth, consistent with our hypothesis that tau reduction protects against Aβ by preventing neuronal overexcitation (Roberson et al , 2007), targeted perturbation of the NR PSD-95 interaction, which prevents excitotoxicity, also prevented premature mortality and memory deficits in APP23 mice
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