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Canada-71851-DENTURISTS företaget Kataloger
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- Surplus fat rapidly increases fat oxidation and insulin . . .
These data suggest that when adipose storage reserves are saturated, excess fat intake necessarily increases fat oxidation and induces oxidative substrate competition which exacerbates insulin resistance resolving any residual energy surplus through excretion of glucose
- Adipose tissue and insulin resistance in obese
Dietary fat is much more energy-dense than protein and carbohydrates, but it has less potential to inhibit food intake and evoke insulin secretion [80]; therefore, it is assumed that surplus dietary fats are positively associated with increased obesity
- Surplus fatty acid synthesis increases oxidative stress in . . .
Here, we show that surplus fatty acid synthesis in adipocytes induces necroptosis and lipodystrophy Transcriptional activation of FASN elevates fatty acid synthesis, but decreases NADPH
- Obesity, insulin resistance and comorbidities – Mechanisms of . . .
High levels of circulating catecholamines lead to insulin resistance One of the outcomes of increased adrenergic outflow is increased lipolysis which promotes excessive influx of FFA to the cells Obesity, especially visceral, is associated with increased SNS activity
- Metabolic Flexibility and Its Impact on Health Outcomes
When energy supply exceeds demand across the mitochondria, as with a sedentary lifestyle, deposition of fat in non-adipose tissue occurs and is associated with insulin resistance and the metabolic complications of obesity
- Mechanism of insulin resistance in obesity: a role of ATP
The energy surplus may induce insulin resistance through the activation of many signaling pathways In current concepts, the signaling molecules of insulin resistance include serine kinases (such as JNK, IKK, PKC, and Akt mTOR S6K), reactive oxygen species (ROS), diglycerides (DAGs), and ceramide [3,4] These factors trigger insulin resistance
- The Impact of Oxidative Stress on Adipose Tissue Energy Balance
Obesity and comorbidities increase ROS and decrease antioxidants in adipose, leading to oxidative stress and further complications of obesity, including insulin resistance and diabetes
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