- Transcytosis of Macromolecules at the Blood–Brain Barrier
This evidence has been clearly over-interpreted in the intervening years to imply that endocytosis and transcytosis at the BBB either do not occur or are insignificant Adapted from Weisz and Rodriguez (29B4) covalently attached to albumin nanoparticles to deliver loperamide to the mouse CNS The CNS activity of loperamide was assessed
- Ora Weisz, Ph. D. | Integrative Systems Biology - University of Pittsburgh
The Weisz lab uses imaging, biochemical, genomic, and modeling approaches in highly differentiated cell cultures and in animal models to study the regulation of membrane traffic in the kidney proximal tubule (PT) Raghavan V, Rbaibi R, Pastor-Soler N, Carattino MD, and Weisz OA (2014) Shear stress dependent regulation of apical endocytosis
- PUBLICATIONS - WEISZ LAB
Raghavan V and Weisz OA (2015) Flow stimulated endocytosis in the proximal tubule Curr Opin Nephrol Hypertens 24:359-365 PMCID: PMC4494861 PDF Little M, Brown D, Humphreys B, McMahon A, Miner JH, Sands JM, Weisz OA, Mullins C, and Hoshizaki D (2014) The critical value of defining kidney biology to understanding renal disease
- COPINION Flow stimulated endocytosis in the proximal tubule
apical endocytosis was observed in MDCK type II cells, which have hybrid characteristics of proximal and distal tubule cells [28 ,31] Endocytosis from the apical surface of differen-tiated kidney cells occurs exclusively at the base of microvilli via a clathrin-dependent, dynamin-dependent, and actin-dependent pathway [32–37]
- Megalin as a Metabolic Modulator in the Kidney and Beyond
The Weisz group previously demonstrated that proximal tubule endocytosis and transcription are intricately linked 2, 3 In particular, Lrp2 knockout in highly differentiated cultured proximal tubule cells led to the differential expression of over 400 genes 2 Notably, the transcriptional response to megalin knockout was much more robust compared to that observed with the endocytic adaptor
- Ora Weisz, PhD | Physician Scientist Incubator - University of Pittsburgh
Eshbach ML, Weisz OA Receptor-Mediated Endocytosis in the Proximal Tubule Annu Rev Physiol 2017 Feb 10;79:425-448 doi: 10 1146 annurev-physiol-022516-034234 Epub 2016 Oct 28 Review PubMed PMID: 27813828; PubMed Central PMCID: PMC5512543 Pereira EM, Labilloy A, Eshbach ML, Roy A, Subramanya AR, Monte S, Labilloy G, Weisz OA
- Ora Weisz - Google Scholar
Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia V Raghavan, Y Rbaibi, NM Pastor-Soler, MD Carattino, OA Weisz A Oztan, M Silvis, OA Weisz, NA Bradbury, SC Hsu, JR Goldenring, Molecular biology of the cell 18 (10), 3978-3992, 2007 159:
- Flow-stimulated endocytosis in the proximal tubule - Ora Weisz
Weisz, Ora A University of Pittsburgh, Pittsburgh, PA, United States Search 39 grants from Ora Weisz Search grants from University of Pittsburgh This proposal is focused on understanding whether PT cells also adjust the capacity of megalin-and cubilin- mediated endocytosis of LMW proteins in response to altered demand Defective uptake of
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