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- Degenerative Myelopathy (DM) | Veterinary Genetics Laboratory
Degenerative myelopathy (DM) is an inherited neurologic disorder of dogs characterized by gradual muscle wasting and loss of coordination typically beginning in the hind limbs Testing is most appropriate for those breeds in which the clinical disease has been associated with the SOD1 allele
- Degenerative Myelopathy - OFA
In every breed that has been evaluated, Degenerative Myelopathy is associated with the same mutation in the SOD1 gene In addition, a second SOD1 mutation associated with this disease also occurs in some Bernese Mountain Dogs So, for this breed only, testing for both mutations may be advisable
- Degenerative Myelopathy Testing in Dogs | DDC Pets Vets
How do I Know if my Dog Carries the Mutation for DM? Degenerative Myelopathy (DM) is a devastating degenerative disease of the spinal cord that can progress rapidly and cause weakness in the hind limbs—and eventually paraplegia—in affected dogs Our DM DNA test, which uses the SOD1-A marker, is available for all dog breeds
- Degenerative Myelopathy - MU Veterinary Health Center
In 2009, a mutation in the gene superoxide dismutase 1 (SOD1) was described to underlie the cause of DM Dogs that have two copies (homozygous) of the mutant allele have been shown to be at risk for developing DM
- Testing of dogs: DM* (SOD1A) - Genomia
Only in Bernese mountain dog, this degenerative myelopathy can be caused by other mutation in the SOD1 gene, which replaces the nucleotide A with the nucletiode T (c 52A>T; SOD1B) This mutation is however much more rarely than the mutation c 118G>A
- What does the Degenerative Myelopathy (SOD1A) result mean for my dog or . . .
If your dog's test results show one copy of the SOD1A mutation associated with DM, it means that they carry a single copy of the mutated gene and are considered a "carrier" of DM Carriers usually do not exhibit symptoms of the condition but can pass the mutated gene to their offspring
- Degenerative Myelopathy DNA Testing for Canine DM - AffinityDNA
Our Degenerative Myelopathy DNA Testing is a fast and effective way of determining whether or not your dog has the potential to develop Degenerative Myelopathy (DM), or pass it on to any offspring
- Diagnosing Degenerative Myelopathy - Veterinary Teaching Academy
The current thinking about DM is that only dogs with two copies of the mutated SOD1 gene have a high likelihood of developing DM A dog must have both the alleles (that is, A A homozygotes) to develop DM
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